Not surprising, trump doesn’t have a grasp of how dire the situation is about to become. He’s more thinking about getting the economy going so as to not jeopardize his chance for re-election. He’s willing to sacrifice people’s lives to the virus for his own purposes.
Florida man with coronavirus says drug touted by Trump saved his life
- Thread starter lenny
- Start date
"My fellow Americans. I'm aware that some of you will get infected, and have to endure weeks of gasping agony in an overwhelmed ICU. Or you may die alone, like those seniors in the Spanish retirement home, who were abandoned by their terrified caregivers.
But that's a sacrifice I'm willing to make. Can you not think of the economy?"
But that's a sacrifice I'm willing to make. Can you not think of the economy?"
He is an oncologist, not an immunologist. You would be surprised how ignorant most doctors are when it comes to what drugs are and how they work. Their thought process goes something like "drug X is used for condition Y", they generally don't know how or why it might work. They think of drugs as black boxes essentially that do something but they have no idea what is going on inside. MDs who also have a Ph.D. and are involved in medical research may be better informed but not always, especially when it involves something outside of their specialty. Also, he is not running a clinical trial, there is no placebo group and his numbers are small. He is just guessing basically.
Whenever you have something new going on in medicine there will always be some guy that jumps in to make public announcements on whatever they are promoting with limited or no data to back them up. It is human nature. Basically what they are hoping for is they are lucky and whatever bandwagon they are hyping up turns out to be the right wagon. That way they get brownie points and praise for "being the first". If they turn out to be wrong, then no one remembers that they were pushing it, so no harm done. It always happens.
Chloroquine and hydroxychloroquine inhibit acidification of endosomes and lysosomes. Since acidification of these organelles is an important step in the processes that viruses use to cross endosome membranes into the cytoplasm, if you can reduce that you should reduce the ability of a virus to infect a cell. That happens in vitro, but the results are not replicated significantly in clinical trials that have been conducted. Clinical trials with other viruses have shown no protective effect or improvement in duration or severity of disease. So it is not like this is a new thing. The drugs also have an immune modulation effect because proper functioning of these organelles is important in how some components of the immune system work, but the effect is moderate.
A number of different antimalarial drugs have been studied for use against various viruses over the years for these reasons, but so far the outcomes have been minor at best.
If you are interested you can read a review on the subject here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022795/
Not general lifting, just workplace, with precautions in place, to try to get people working, and keep the economy from collapsing.
And he hasn't done it, he's thinking about it. CNN's coverage has been constant, and unreliable when it comes to anything Trump. They have been implying he's going to tell everyone to start behaving like when things were normal. You know, like a few weeks ago.
Meanwhile, the Democrats say they're going ahead with their convention in July. Can you imagine the reaction if Trump made that announcement for a Republican convention?
No one really knows what he is thinking of doing. The point is, at a time when he needs to show leadership to contain this epidemic, he is sowing confusion. He is literally kicking the chair out underneath his health officials. This is bad for everyone, not just Americans.
By the way, I don't get my news from CNN.
That study starts with:
"In recent decades, drugs used to treat malaria infection have been shown to be beneficial for many other diseases, including viral infections."
And ends with:
"Based on these observations, we can state that the use of antimalarial drugs might be useful, especially in cases of antiviral resistance and in light of the emergence of many viruses against which effective drugs are not available."
Of course it doesn't consider success after success with the drug in combating COVID-19, since it was written before then, such as, for example:
"Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies."
https://www.ncbi.nlm.nih.gov/pubmed/32074550
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Go to 17:00 of video
"Chloroquine: A Promising Coronavirus Treatment?"
https://www.youtube.com/watch?v=rRgnQs6D1u8
"Chloroquine: A Promising Coronavirus Treatment?"
https://www.youtube.com/watch?v=rRgnQs6D1u8
Oh so you do watch CNN, where today they showed trump HIMSELF saying that by Easter he would like to see everyone back to work.
With precautions in place? Are you kidding? When thousands in certain areas are walking hotzones like the capitol
of the economy, NY state? Please............. This man is seriously delirious dude. You can't sache' around an epidemic
wishing it away like a bad dream. "WHY DOES HE TALK SHIT IN SPADES?"
(Yes they did show the entire news conference once again of a man who can not put together a coherent sentence)
That certainly sounds like trump saying things will be back to normal before anything had happened. His own words dude.
"Keep America greatly misinformed" is this presidents moniker or signature of retard billboard bullshit.
Only that CNN was there to report it.
And btw, how many rallies has fuckhead had while this corona virus thing was going on. Spewing endless bullshit as he
always does and the inbread minions and lemings lapping it all up. SICKENING DUDE!!!!!!!!!!!
"ohhh, and the Corona virus it's a democrat hoax, let's blame it on the dems". "Earlier this month from the chosen one himself"
"The extremely stable genious" Self proclaimed. Again by the "chosen one"
Not reported by CNN but reported on BEHALF of CNN of TRUMP SAYING IT HIMSELF.
Remember these points as time goes on. For that matter as times HAS gone on.
So tell me, how is that unreliable when it comes to anything "trump"????????
I hope this prick gets covid himself so the world can be rid of this scurge of a human being.
God forgive me that I could wish that on anyone.
Last note to bring up. The dems saying they will have a rally in July is quite a long while after Easter
uhhhh, like 3 MONTHS!! but hey they haven't confirmed it yet. LOL!!!
You have one thing right about CNN's coverage of trump. It has been
constant and for good reason. Trump gives the media a good mark to report on/about especially when
it comes to someone who is not shooting himself in the foot, only because he's reloading his gun.
ound:ound:ound:Just ask Dr. Anthony Fauchi.
......................QM'r
You're on the right track Horn_dawg!!.................LOL!!!
.........................QM'r
And just before that they say: "Nevertheless, some drugs have already been used in several clinical trials, as summarized in Table 1. Most of them regard the use of antimalarial drugs against HIV infection, but some of them failed, and for others, the final results are not available. "
There was a trial run against one of the previous flu outbreaks involving around 1500 patients. It showed no significant effect. Since the flu presents more or less the same sorts of challenges that covid-19 does, the outcome will likely be the same.
The review says this about it:
"Chloroquine and Hydroxychloroquine and Other RNA Viruses:
CQ was shown to inhibit the in vitro replication of H1N1 and H3N2 IAV strains [159]. A phase II clinical trial aiming to verify the effect of CQ compared to that of placebo on IAV was started in Singapore in 2005, and 1516 patients were recruited. However, CQ was not shown to prevent infection with IAV"
Here is another one, also with influenza, that suggests that these drugs can actually make the infection worse: https://www.ncbi.nlm.nih.gov/pubmed/25715935
"Time-of-addition assay showed that inhibitory effect on virus replication by chloroquine pre-treatment was indistinctive, and virus productions were enhanced when the drug was applied after viral adsorption. The effectiveness of chloroquine as an anti-influenza drug is questioned, and caution in its use is recommended."
Now I can't say if that study is any good or not, but there is stuff out there that suggests that there may be risks involved, especially when it comes to timing of administration.
The irony is that his base will likely take a much bigger hit from the virus than the democrat's base.
Apples & oranges, hence all irrelevant. The recent usage & apparent successes of (hydroxy)chloroquine have nothing to do with "prevent(ing) infection" of COVID-19, but post infection treatment. Moreover the best success results were when it was used in combination with another drug.
They are currently being used as part of a trial at the North Vancouver care home that has infected patients.
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"Michigan Democratic lawmaker says hydroxychloroquine saved her life"
https://nypost.com/2020/04/07/michigan-democrat-says-hydroxychloroquine-saved-her-life/
https://nypost.com/2020/04/07/michigan-democrat-says-hydroxychloroquine-saved-her-life/
I'm sorry. The headline is sensationalized. The fact that she's a Michigan Democratic lawmaker is irrelevant in the context of what the story should be trying to portray.
She's a lawmaker, not a doctor, she has no idea what saved her life. Could it be hydroxychloroquine? Sure, but I'm going to take the word of a professional instead of someone who can't tell the difference between medicine and a perfect storm.
Of course this one case does not prove the effectiveness of the drug or anything. That's why there are several groups that are going to conduct proper large scale trials. Several smaller trials have already been completed & thousands of people have also been given the drug (with or without other drugs) in hospitals or via clinics, etc. The FDA approved its use on an emergency basis & under certain conditions.
