Had a buddy, good looking guy, used to get a bit liqoured up and start asking women "Hey, how about a beer and a fuck?". For the 19 out of 20 that would react with revulsion or anger, he'd respond "What, you don't like beer?"
Amazingly, 1 out of 20 would actually ask for the beer... and shortly thereafter, they'd leave....
My sister had a great response for bad pickup lines, after the gentleman would pose his quiet question, she would say in a loud voice "Fifty Dollars?!?" and look at him with scorn. They usually melted back into the crowd, tail between thier legs...
Still think one of the all time favourite pick up lines was Kevin Costners monologue in Bull Durham... got to watch that again, and take some more notes...
Rubin