18th & Main is one of the hottest areas in the city for real estate. Prices in the area have doubled in the last few years & houses often sell in a few days for over the asking price.
Surrounding areas such as Fraser take up the slack.
Depending on what kind of neighbourhood & property you're after & what your budget is, Fraser could be a good choice. Having said that, don't base a quarter million dollar plus housing purchase on info from an escort review board!
Don't you have a realtor?
ps. there are no sw's on main/fraser & 18th, the areas are close to a few happy ending hair salons (& a few incall indies) but hey, it's vancouver..part of the local culture.