Define safe.
Safe from LE? Safe from being scammed? Safe from STIs? Safe from assault?
Safe from LE
Yes - if you use an independent escort using outcall to a hotel & negotiate the deal in the privacy of the hotel room. This steers you clear of bawdy house laws, communicating laws & knowingly contributing to living off the avails.
Safe from being scammed
No. You are more likely to encounter a scam or bait & switch operation when not using a MP or micro.
Safe from STIs
No difference in the risk factors & how to mitigate for them.
Safe from assault
Again, risks of meeting the "boyfriend" rise when not dealing with a bricks & mortar business. But rise is a relative term.
Now the final caveat you should really consider is that this hobby is a huge trade. There are an enormous number of perfectly safe & satisfactory sessions occurring every day & the risks of any of the above occurring are quite low.
Stick to the well reviewed SPs if you have concerns. If you are still afraid, pick a different hobby.