Interesting thread. Although evolution provides a very good explanation for how life develops once has been established, I don’t know that it’s the panacea that it’s made out to be; I think that one of its weaknesses is being able to explain how life can begin in the first place. Even if you look at the simplest single-celled organism, such as a primitive virus, that cell is still an amazingly sophisticated structure, with complexity existing at many different levels. There is still a huge gap between going from inorganic molecules and atoms to a single cell that is very difficult to account for based on chance alone.
When I was in university, I remember one of my Biochemistry professors talking about how the focus was on self-replicating molecules as a proposal to bridge this gap. He was working on self-replicating RNA, but I believe that the focus is now on self-replicating proteins. But even this is a very wide chasm to bridge, at least in my opinion. Organic molecules are relatively difficult to synthesis in the laboratory, where we are working with highly purified materials and tightly controlled conditions that typically don’t occur in nature. And that’s just for an amino acid. A protein is typically tens to hundreds of amino acids long, Even if you wanted to make a protein of just ten amino acids, you first need to synthesize the amino acid, and not just a few amino acids, but most likely thousands or even millions of them as the chance of side reactions occurring would be, I would think, quite high given that, in the natural world, you are working in conditions with high levels of contaminants and impurities that can interfere with the synthesis. And then have the amino acids brought close enough together so that a condensation reaction can occur and they can join together. In a small reaction vessel, sure, this is very possible, but in a natural environment we’re probably dealing lakes or oceans. Even a small puddle would be a very large area for small molecules to traverse and meet up. And they have to stay joined and not be separated via a hydrolytic reaction. This event would have to occur not once, but several times in order to produce a somewhat functional protein. Actually, it would probably have to occur at an even higher frequency as the chances of the first protein formed having the right sequence of amino acids to produce functional capabilities is unlikely. Also, that function needs to relate to self-replication. And that’s just one protein.